A fire Friday night and Saturday morning left the New Harvest Christian Center in ruins.
The Anniston fire Department responded to the "big and tough fire" at 3511 Alexandria Road near Saks.
More than half of the 21,000-square-foot was destroyed, a tour of the property Sunday night showed.
"I am sure many of you have seen the photos of our church," pastor James Patterson on wrote on Facebook. "Please keep my church family in your prayers as we go through and process this whole ordeal.
"It's a lot, but God will see us through. I cried a lot last night," he added.
The blaze required nearly every available on-duty Anniston firefighter.
"They overcame several obstacles and every truck in the department was on scene for several hours," Anniston Fire said on its Facebook page.
The Anniston crew was assisted by the Anniston Army Depot Fire Department on the scene.
The Oxford and Jacksonville fire departments assisted on calls in Anniston while the city's crews were at the church.